Reaction Control
Reaction control with PAT-guided setpoints.
Pharmaceutical API
Polymorra
Autonomous operations layer for pharmaceutical API (small-molecule drug-substance) manufacturing — reaction and crystallisation control with PAT sensing.
Overview
What Polymorra does.
Polymorra closes the loop on pharmaceutical API manufacturing: reaction and crystallisation control with PAT sensing, isolation and drying, continuous and flow chemistry, review-by-exception, robotic sampling and the reactor and crystalliser twin.
Every campaign produces labelled process traces that train the next model, tightening the loop from feed to isolated drug substance.
| Detail | Value |
|---|---|
| Stage | Seed |
| Category | Physical AI |
| Year | 2026 |
| Website | polymorra.com |
| Headquarters | Not disclosed |
| Raised | $1.5M |
| Investor | 10xC |
| Model | Per-reactor software subscription with a yield-outcome component. |
| Measured by | Yield and particle-size conformance, batch-release time, PAT uptime, reactors expanded per customer. |
Products
One loop, module by module.
Every deployment on polymorra.com writes labelled traces back into the model, so the system generalises across plants, alloys, grades and geometries.
Crystallisation Control
Crystallisation control for particle-size and yield.
PAT Sensing
In-line PAT sensing for concentration and supersaturation.
Isolation & Drying
Isolation and drying control.
Continuous & Flow
Continuous and flow chemistry orchestration.
Review-by-Exception
Review-by-exception batch release.
Reactor & Crystalliser Twin
Reactor and crystalliser digital twin.
Robotic Sampling
Robotic sampling for at-line analytics.
Why we invested
The thesis behind Polymorra.
API manufacturing runs on process scientists and on off-line HPLC that reports hours after the reactor has moved on. Crystallisation is decided once and cannot be repeated in the same batch.
Polymorra reads the batch as it runs and closes the loop into reactor control. The buyer is a CDMO or API manufacturer paying in hard currency; the wedge is one reaction or crystallisation step, and yield and particle-size conformance are the numbers that open the next module.
Who is building it
Co-Founder & CEO
Co-Founder & CEOOwns the CDMO relationships, the pilot programme and the commercial model.
Co-Founder & CTO
Co-Founder & CTOOwns the reactor and PAT models, the edge runtime and the GMP-grade audit architecture.
Building something similar?
Building in Physical AI? We want to hear about it.